Which of the following statements is TRUE of the ligands of

Which of the following statements is TRUE of the ligands of nuclear receptors?

A

They are hydrophobic.

B

They may activate transcription factors.

C

They include steroid sex hormones, retinoids, and vitamin D.

D

A, B, and C

E

None of the above

Solution

Answer is option D)- A,B and C.

Ligands of nuclear receptors are lipophilic that means they are hydrophobic. They include steroid hormones, retinoids, vitamin D3 ,thyroid hormones and fatty acids and phospholipids. Nuclear receptors are ligand activated transcription factors.